Symbol
Name
ID

Srsf2
serine and arginine-rich splicing factor 2
MGI:98284

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia	Subacute progressive viral hepatitis
Disease(s) Associated with SRSF2	Acute myeloid leukemia	Subacute progressive viral hepatitis
acute myeloid leukemia
hepatocellular carcinoma

Mouse Phenotypes

absent thymus corticomedullary boundary

decreased thymus weight

small thymus

decreased thymocyte number

abnormal T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

abnormal myelopoiesis

failure of myelopoiesis

abnormal neutrophil morphology

decreased B cell number

decreased T cell number

abnormal spleen white pulp morphology

bone marrow failure

Availability

Mouse Genotype

Srsf2^tm1Xdfu/Srsf2^tm1Xdfu
Tg(Lck-cre)I57Jxm/? (conditional)

Srsf2^tm1Xdfu/Srsf2^tm1Xdfu
Tg(Mx1-cre)1Cgn/? (conditional)

Srsf2^tm1.1Oaw/Srsf2⁺
Tg(Mx1-cre)1Cgn/? (conditional)

Srsf2^tm1Xdfu/Srsf2⁺
Tg(Lck-cre)I57Jxm/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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